Observou-se um caso de resistência à eritropoetina recombinante humana causada por Ectasia Vascular Antral Gástrica em uma mulher de 40 anos de idade. Abstract. DAL MASO, Rosina Conceição Graçaplena et al. Sex hormones in women on dialysis. Rev. Assoc. Med. Bras. [online]. , vol, n.4, pp . 22 out. Observou-se um caso de resistência à eritropoetina recombinante humana causada por Ectasia Vascular Antral. Gástrica em uma mulher de.
|Published (Last):||6 August 2010|
|PDF File Size:||6.15 Mb|
|ePub File Size:||1.29 Mb|
|Price:||Free* [*Free Regsitration Required]|
In the central nervous system, EPO is involved in neuroprotection, neurogenesis and angiogenesis, playing an important function as a neurotropic and immunomodulatory factor The first available drugs were epoetin alfa and epoetin beta, two forms of recombinant EPO, both highly effective, but with erltropoetina short duration of action administration 3 times a week: Kidney Int ;67 4: Lacombe C, Mayeux P.
Similar Items Eritropoetina humana recombinante na anemia de prematuridade: The histologic findings are recpmbinante proliferation and capillary ectasia with microvascular thrombosis of the lamina propria.
Since its discovery, much has been achieved in the knowledge of the biology of this glycoprotein. However, these histologic findings are not necessary to confirm the diagnosis.
Sign in to the Lens
Hypoxia inducible factor HIF system: In adult livers, EPO mRNA levels increase under moderate to severe hypoxia conditions, being one of the most important sources of extrarenal EPO, although insufficient to normalize haemoglobin in chronic kidney disease CKD. The introduction of rHu-EPO revolutionized the treatment of CKD patients, enabling a long-term safe management of anaemia, without risks associated with blood transfusions. Argon photocoagulation in the treatment of gastric antral vascular ectasia and radiation proctitis.
The etiology of GAVE syndrome remains unknown and has been associated with several disease states, including autoimmune disease e. Services on Demand Journal. In monkeys, its administration resulted in effective iron mobilization, with increased serum levels Chronic kidney disease is characterized by renal impairment of glomerular function, tubular and endocrine, slow, progressive and irreversible, with anemia as a major complication, whose intensity and prevalence are related to the stage of kidney disease and disability in production erythropoietin EPO.
Apart from the kidney, EPO mRNA expression was also detected in non-haematopoietic tissues, such as brain neurons and glial cellslungs, heart, bone marrow, spleen, hair follicles, reproductive system, pancreatic islets and osteoblasts 7,8. In addition to its antimicrobial properties, hepcidin controls the amount of iron absorbed in the duodenum and the release of iron from the reticuloendothelial system cells such as Kupffer cells and splenic macrophages by ferroportin internalization and degradation, which is expressed in duodenal enterocytes, hepatocytes and macrophages The EPO production in the kidney and liver stimulates erythropoiesis and an additional need for iron that leads to an increase in intestinal iron absorption and iron binding capacity, as well as an increase in iron release from body iron stores.
Regulação da produção da eritropoietina e perspectivas terapêuticas na anemia
Regular transfusions increased the risk of infection, iron overload and anti-HLA human leukocyte antigen antibodies development, reducing the likelihood of a successful renal transplantation. Non-cirrhotic patients are more likely to have classic watermelon stomach.
Thus, anticipating an ischaemic insult for example, kidney transplantation or renal arteries clamping during abdominal surgeryrecombinant EPO can be used as a kidney tissue protector. The new erythropoietic stimulators, summarized in Table I.
Am J Pathol ; 4: Additionally, the uraemic environment associated with chronic inflammatory status contributes for erythrocyte survival decrease and erythropoiesis inhibition. We will mainly focus on EPO production, regulation and functions, taking also into account current therapies and new options for anaemia treatment.
The serum concentrations of PRL were above the normal range in all groups. Escorcio, Carla Solange de Melo Published: There are two GATA inhibitors reported: About 30 years ago, the treatment of chronic renal disease anaemia was revolutionized by the introduction of recombinant human erittopoetina, which reduced the need for blood transfusions. Antinuclear antibodies were negative.
In persistent failure of endoscopic therapy will be performed surgical procedure.
J Gastrointest Surg ;7: A large proportion of CKD patients develop anaemia over the course of their disease, which is a risk factor associated with worse prognosis, either as an independent predictor factor humxna as a risk multiplier in patients with concomitant cardiovascular disease Later she presented recurrent melena, hematemesis and hypotension Mean Arterial Pressure: Iron, inflammation, dialysis adequacy, nutritional status, and hyperparathyroidism modify erythropoietic response.
Impact of haemoglobin and erythropoietin dose changes on mortality: